Winston Patrick Kuo, DDS, MS

winston_kuo@hms.harvard.edu

Biomedical Informatics Research Fellow

(see )

• Bioinformatics
• Gene expression

Technology issues: Large-scale analysis to address the issues of comparative advantages and disadvantages amongst these different microarray platforms.

Oral cancer: the ability to predict the biology ofpre-malignant lesions has been limited by controversial clinical terms, inaccurate and subjective assessments due to lack of well-defined criteria for grading, and the lack of genotypic/phenotypic-based biomarkers from gene expression profiles.

Cranio-facial development and malformation: identify candidate genes that will represent distinct signaling pathways and region-specific transcription factors with important developmental functions as well as understanding those involved in malformations in the cranium.

Evolution: Comparing expression profiles of several species (Darwin’s finches) representing distinctmorphologies, we expect that these candidates will represent distinct signaling pathways and region-specific transcription factors with important developmental functions.

Blackshaw, S, Kuo, WP, Park, PJ, Cepko, CL. (2002) MicroSage is highly reproducible, but reveals major difference in gene expression among samples obtained from identical tissues, Genome Biology, accepted.

Kuo, WP, Whipple, ME, Jenssen, TK, Todd, R, Ohno-Machado, L, Park, PJ (2002) Microarrays and Clinical Dentistry, Journal of the American Dental Association, accepted.

Kuo, WP, Whipple, ME, Jenssen, TK, Ohno-Machado, L, Lingen, MW. (2002) Classification and Identification of Genes Associated with Oral Cancer Based on Gene Expression Profiles - Preliminary Study, New York State Dental Journal, accepted.

Ohno-Machado, L, Vinterbo, S, Dreiseitl, S, Jenssen, TK, Kuo, WP. (2002) Comparing Imperfect Measurements with the Bland-Altman Technique: Application in Gene Expression Analysis, Proceedings American Medical Informatics Association Symposium, 572-576.

Kuo, WP, Jenssen, TK, Park, PJ, Lingen, MW, Hasina, R, Ohno-Machado, L. (2002) Gene Expression Levels In Different Stages of Progression in Oral Squamous Cell Carcinoma, Proceedings American Medical Informatics Association Symposium, 415-419.

Jenssen, TK, Kuo, WP, Stokke, T, Hovig, E. (2002) Associations between gene expressions in breast cancer and patient survival,Human Genetics,111(4-5):411-420.

Todd, R, Lingen, MW, Kuo, WP. (2002) Gene Expression Profiling using Laser Capture Microdissection, Expert Reviews in Molecular Diagnosis,2(5):497-507 (Invited Technology Report).

Jenssen, TK, Langaas, M, Kuo, WP, Smith-Sorensen, B, Myklebost, O, Hovig, E. (2002)Analysis of repeatability in spotted cDNA microarrays, Nucleic Acid Research, 30(14): 3235-44.

Kuo, WP, Jenssen TK, Butte AJ, Ohno-Machado L, Kohane IS.(2002) Analysis of matched mRNA measurements from two different microarray technologies,Bioinformatics,18(3):405-412.

Kuo, WP, Whipple, ME, Sonis, ST, Ohno-Machado, L, Jenssen TK. (2002) Gene Expression Profiling by DNA Microarrays and its Application to Dental Research, Oral Oncology, 38(7): 650-656.